ailanthone
- Product Name
- ailanthone
- CAS No.
- 981-15-7
- Chemical Name
- ailanthone
- Synonyms
- ailanthone;Δ13-Dehydrochaparrinone;13,21-Didehydrochaparrinone;2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6aH);(1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras...;11β,20-Epoxy-1β,11,12α-trihydroxypicrasa-3,13(21)-diene-2,16-dione;(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione;Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-;Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-
- CBNumber
- CB71327541
- Molecular Formula
- C20H24O7
- Formula Weight
- 376.4
- MOL File
- 981-15-7.mol
ailanthone Property
- Melting point:
- 235-237 °C
- Boiling point:
- 641.0±55.0 °C(Predicted)
- Density
- 1.47
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);265.67(Max Conc. mM)
- form
- A crystalline solid
- pka
- 11.85±0.70(Predicted)
- LogP
- -0.760 (est)
N-Bromosuccinimide Price
- Product number
- SML2143
- Product name
- Ailanthone
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $143
- Updated
- 2023/06/20
- Product number
- SML2143
- Product name
- Ailanthone
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $567
- Updated
- 2023/06/20
- Product number
- 29194
- Product name
- Ailanthone
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29194
- Product name
- Ailanthone
- Packaging
- 25mg
- Price
- $485
- Updated
- 2024/03/01
- Product number
- 29194
- Product name
- Ailanthone
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
ailanthone Chemical Properties,Usage,Production
Description
Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.
Uses
Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo.
Definition
ChEBI: Ailanthone is a triterpenoid.
ailanthone Preparation Products And Raw materials
Raw materials
Preparation Products
ailanthone Suppliers
- Tel
- 1-631-485-4226; 16314854226
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- Country
- United States
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- 14059
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- 702-983-3769
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- United States
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- 888-539-0666
- Fax
- 888-539-0666
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- United States
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- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
- Advantage
- 58
View Lastest Price from ailanthone manufacturers
- Product
- ailanthone 981-15-7
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-10